Issue 005 · June 29, 2026

Quarter Millennium

A short, patriotic week — the semiquincentennial, a new fiscal year, and two binding sites.

Happy Monday

Welcome to a short week, and not just any short week: the week that is short because of the upcoming semiquincentennial (or, alternatively, sestercentennial or Quarter Millennium) of the United States of America. Imagine: nearly two hundred and fifty years ago, a group of wealthy landed white men got so tired of paying taxes to their tyrannous overseas rulers that they wrote a whole blog post about it called the Declaration of Independence. Then, a bunch of stuff happened, and here we are. What a world!

In addition to being the week of the celebration of the Founding of Our Great Nation, this Wednesday is also July 1st, which marks the beginning of Sutter Hill’s new fiscal year. That means we will be kicking off execution of our strategic goals for the year in earnest. That includes continuing to build relationships with both strategic and capital partners for our portfolio companies, exploring and developing ex-US connections that can accelerate our portfolio’s preclinical and clinical development plans, and ensuring that our internal company-building infrastructure can scale sustainably and economically.

Watch this space for more communication in the coming days and weeks about the above. Until then, try not to go too nuts with the glizzies this Fourth of July, and if you can, try to best my Most Patriotic Garment: a blue tank top with a logo in the shape of the Liberty Bell, in Stars and Stripes colors, made up of the words of the Declaration of Independence. The mere sight will kill a redcoat at ten paces. Please submit any attempts at an Even More Patriotic Garment via email.

Binding Sites

  1. What Ethiopian running says about the limits of human ability To the casual observer (of which I consider myself one), East African dominance of endurance running sports is an empirical fact often chalked up to genetics and geography. This essay calls that assumption into question, comparing the exacting data-driven engineering methods of Western sports science to the very different, but no less scientific, approach of Ethiopian distance runners.
  2. Trends in the landscape of clinical trials of innovative drugs in China since 2015 Good review of clinical development trends in China over the past decade. At a high level, the data indicates (unsurprisingly, if you watch this space) that China has matured and expanded massively as a clinical development venue, while remaining highly concentrated in oncology and well-validated, crowded targets.